Some of the most common unanswered questions are:
How did everything start?
What was there before?
How was something made from nothing?
What came first, the chicken or the egg?
When you consider that there are billions of stars in our galaxy and billions of galaxies in the universe (let alone mentioning planets), it looks inevitable that there is life outside of our planet. On top of this, research has shown that life can thrive in seemingly inhabitable environments, not to mention that we only view a small spectrum of reality through our eyes (our brains only decode a small spectrum of waves).